Expression of S100B Protein in the Placenta and Umbilical Cord of the Pregnant Women at Different Gestational Ages
- VernacularTitle:不同孕龄产妇胎盘和脐带组织中S100B蛋白的表达
- Author:
Xuemin LIU
;
Juan DU
- Publication Type:Journal Article
- Keywords:
brain injury;
S100B piotein;
placenta;
umbilical cord
- From:
Journal of China Medical University
2009;(10):781-782,789
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and localization of S100B protein in the placenta and umbilical cord tissue of the pregnant women at different gestational ages. Methods The placenta and umbilical cord tissues were obtained from 60 healthy pregnant women at different gestational ages:13～27 weeks (a = 20),28～36 weeks (n = 20),37～41 weeks (n = 20). The localization and expres-sion of S100B protein was detected by S-P immunochemical method and Western blotting. Results In the placenta,the S100B protein lo-cated in the trophoblast.myofibroblasts.macrophages and smooth muscle cells. The intensity of immunostaining and protein concentration in-creased with advancing gestation. In the umbilical cord,the S100B protein was found in the smooth muscle cells,myofibmblasts,amnion ep-ithelium, macrophages and monocytes. S100B piotein expression showed no significant difference in the different cells of the umbilical cord. Conclusion S100B protein expression in the placenta and umbilical cord tissues is throughout the gestation and increases with advancing gestation in the placenta.
