A study on the collagen metabolism and therapy of hepatic fibrosis
- VernacularTitle:肝纤维化的胶原代谢及其相关治疗的研究
- Author:
Shuangying GUI
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
hepatic fibrosis;
collagen metabolism;
antifibrotic therapy
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is the hallmark of most chronic liver diseases. Its essense is excessive deposition of extracellular matrix components(ECM) in liver, which occurs due to an imbalance between the production and degradation of matrix. Collagen is the most important part of ECM. Therefore,one important antifibrotic pathway is to effectively inhibit the synthesis of collagen or increase its degradation. The review describes the current progress in collagen metabolism and antifibrotic therapy related to hepatic fibrosis.
