Pharmacological characteristics of homologous upregulation of nicotinic ?_7 receptors in brain
- VernacularTitle:脑N受体?_7亚型同源性上行性调节的药理学特征
- Author:
Yue WANG
;
Yue LIU
;
Huaijing WANG
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
choline;
nicotine;
methyllycaconitine;
up-regulation;
nicotinic receptors;
hippocampus
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
10 ?mol?L -1) increased the binding sites of [ 125I] ?-Bgt significantly (P0.05).Conclusion Chronic treatment of choline, nicotine or methyllycaconitine can upregulate the nicotinic ? 7 receptors at certain doses. The effect of choline on upregulation of ? 7 receptors is different from that of nicotine.
