Effects of new derivatives of 1H-isoindole-1,3(2H)-dione on angiogenesis in chick chorioallantoic membranes
- VernacularTitle:1H-异吲哚-1,3(2H)-二酮新衍生物对鸡胚绒毛尿囊膜血管新生的抑制作用研究
- Author:
Jingxia LIU
;
Chaoliang LONG
;
Yonglin YANG
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
new derivatives of 1H-isoindole-1,3(2H)-dione;
angiogenesis;
chick chorioallantoic membranes
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of new derivatives of 1H-isoindole-1,3(2H)-dione on angiogenesis in chick chorioallantoic membranes(CAM). Methods The blood vessels of CAM were calculated to determine the antiangiogenic effects of different new compounds. Results Among the 18 new derivatives of 1H-isoindole-1,3(2H)-dione , compound 1,2,3,4,11 and 13 showed significant inhibition on angiogenesis of CAM.Conculsion The 6 new derivatives of 1H-isoindole-1,3(2H)-dione screened out in this experiment may be novel angiogenesis inhibitors.
