The protective effects of scallop skite-glycosaminoglycan on vascular endothelial cell injury induced by OX-LDL
- VernacularTitle:扇贝裙边糖胺聚糖对OX-LDL致血管内皮细胞损伤的保护作用
- Author:
Junling ZHANG
;
Sai LIU
;
Ruichen WANG
;
Jiju HAN
- Publication Type:Journal Article
- Keywords:
scallop skite-glycosaminoglycan(SS-GAG);
vascular endothelial cell(VEC);
lowdensitylipoprotein(LDL);
atherosclerosis(AS)
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study on the protective effects on vein endothelial cell of scallop skite-glycosaminoglycan(SS-GAG)and the mechanism of anti-atherosclerosis action of SS-GAG.Methods The endothelial cell of human umbilical vein had been cultured in vitro, and we established an model of endothelial cell oxidative damage induced by oxidized low density lipoprotein (OX-LDL), MTT assay and chemical methods were used to test the influence of SS-GAG on proliferation activity of endothelial cell oxidative damage and analyze nitric oxide (NO) and endothelial nitric oxide synthase (eNOS).Results Oxidized lowdensity lipoprotein (OX-LDL) remarkably inhibited the ability of cell proliferation, decreased nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) (P
