Anti-asthmatic effect inhibition of artesunate on the asthmatic model of guinea-pig
- VernacularTitle:青蒿琥酯对豚鼠哮喘模型抑制作用的研究
- Author:
Maosheng YANG
;
Kang HE
;
Weiming XU
- Publication Type:Journal Article
- Keywords:
artesunate;
asthmatic model of guinea-pig;
aminophylline;
acetylcholine;
histamine
- From:
Chinese Pharmaceutical Journal
1999;(3):160-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To study the anti-asthmatic effects of artesunate on the durg-induced asthmat.METHOD:Drug-induced asthmatic model of guinea-pig. RESULTS:Using nubilous inhalation or intragastric administration,artesunate significantly inhibited the guinea-pig model asthma in a dose-dependent manner.It's ED50 were (99.95±7.69)mg.L-1(n=4) and (15.64±1.25)mg.kg-1.d-1(n=4) respectively. CONCLUSION:artesunate showed anti-athmatic effect in guinea-pig asthmatic model.
