Effect and mechanism of selective aldosterone receptor blocker eplerenone on renovascular hypertensive rats
- VernacularTitle:选择性醛固酮受体拮抗剂对肾血管性高血压的作用及机制
- Author:
Lirong HAO
;
Songcen LV
;
Bo DI
- Publication Type:Journal Article
- Keywords:
Aldosterone receptor;
Angiotensin receptor;
Nitric oxide synthase;
Endothelial cell;
Eplerenone
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and mechanism of a selective aldosterone receptor blocker, eplerenone (EP), on renovascular hypertensive rats. Method Forty-eight Wistar rats were divided into six groups: sham operation group, control model group, early EP group, late EP group, early losartan (LO) group and late LO group. Systolic blood pressure (SBP) and urinary protein excretion (UPE) were measured before and every two weeks after operation. Histopathology and endothelial cell nitric oxide synthase (ecNOS) gene expression were examined in heart, aorta and kidney. Results SBP obviously increased in control model group as compared to sham group at week 10(132. 1 ?2.4 vs. 115.0?0.6 mmHg, P = 0. 0191), while early treatment with LO or EP could decrease SBP significantly as compared to control group. The control group developed significant UPE [ (21. 7 ? 1.9) mg/d] compared with the sham group [(13. 4?0. 8) mg/d] (P
