Wnt signal transduction and human tumor
- VernacularTitle:Wnt信号转导与人类肿瘤
- Author:
Jianming ZHENG
;
Minghua ZHU
- Publication Type:Journal Article
- Keywords:
Wnt signal transduction;
?-catenin;
neoplasms
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signal transduction pathway plays a very important role in embryonic development, and its abnormality may lead to developmental defects and cellular malignant transformation. It has been shown that disturbances of the Wnt signal transduction pathway were significantly related to human neoplastic transformation. The core mechanism of the pathway abnormality was the accumulation of free ?-catenin protein in the cytoplasm and nucleus resulting in the expressions of specific target genes by downstream pathway. This paper reviews the composition and structural character, transduction and regulation of the Wnt signal pathway and its relation with human tumorigenesis.
