Transforming growth factor-? and primary open-angle glaucoma
- VernacularTitle:TGF-?与原发性开角型青光眼
- Author:
Qi XU
;
Yinping LIU
;
Lin LIU
- Publication Type:Journal Article
- Keywords:
transforming growth factor-?;
primary open-angle glaucoma;
filtering surgery;
conjunctiva;
cicatrix
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
As a multifunctional cytokine,transforming growth factor-?(TGF-?) has many biological effects. It controls the extracellular matrix synthesis in trabecular meshwork cells and enhances the contractility of trabecular cells,which may increase the resistance of aqueous outflow. It can also promote the formation of the bleb scarring after filtration surgery. TGF-? is likely to play an important role in the pathogenesis and mechanism of primary open-angle glaucoma (POAG). The inhibitions of TGF-? may be used as an auxiliary agent for inhibiting the formation of the bleb scarring after filtration surgery.
