Experimental studies on analgesic and anti-inflammation effects of aspirin -niacinamide-zinc complex (WUY)
- VernacularTitle:阿司匹林-烟酰胺-锌络合物镇痛抗炎作用的实验研究
- Author:
Qisong PU
;
Jun LEI
;
Xiang ZHANG
- Publication Type:Journal Article
- Keywords:
aspirin-niacinamide-zinc complex;
aspirin;
analgesia;
anti -inflammation
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the analgesia and anti-inflammation effects o f aspirin-niacinamide-zinc complex (WUY). METHODS: In this study , the mice ear swelling, vascular permeability increasing and rats’ paw edema w ere adopted to evaluate the anti-inflammable effects of WUY. And the analgesic effects of WUY were tested by writhing reaction and hot-plate method. R ESULTS: In high and low dose groups of WUY, the degrees of ear swelling were 3.3 and 2.8 mg, the Evans blue induced effusion were 3.1 and 1.2 mg?L -1, and the paw edema volume (1-4 h) were 0.21- 0.13 and 0.23- 0.08 ml, respectively. WUY ( 0.3 and 0.45 mmol?kg -1) prolonged incubation period of hot-plate reaction and showed marked i nhibition effects on writhing induced by acetic acid in mice. CONCLUSION : The analgesic and anti-inflammable effects of WUY are stronger than t hat of ASP.
