EFFECTS OF DIFFERENT DIETARY FATTY ACID COMPOSITION ON T LYMPHOCYTE FUNCTIONS AND LIPID PEROXIDATION IN MICE
- VernacularTitle:膳食脂肪酸构成对小鼠淋巴细胞功能和脂质过氧化的影响
- Author:
Meixia PAN
;
Yixiang SU
- Publication Type:Journal Article
- Keywords:
fatty acid composition;
n-6 PUFA;
n-3 PUFA;
immune function
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of dietary n-6/n-3 PUFA ratio on T lymphocyte functions in mice. Methods: 96 male BALb/c mice were randomly divided into 8 groups with dietary S:M:P 1:1.5:3.7 or 1:1.5:1, respectively. The n-6/n-3 PUFA ratio was 1, 7.5, 15, 30 respectively in each S:M:P diet. Each diet contained 70.0g/kg lipid,and different n-6/n-3 PUFA ratios by mixing different oils. At the end of 12w, all mice were killed and blood was collected. The spleen T lymphocyte proliferation, IL-2 production and serum MDA were measured. Results: When dietary S:M:P was 1:1.5:3.7, the proliferation of spleen lymphocytes and IL-2 production from mice with dietary n-6/n-3 ratio 1 were suppressed (P
