THE PROTECTIVE EFFECT OF GLUTAMINE ON INTESTINE IN MICE DAMAGED BY RADIATION
- VernacularTitle:谷氨酰胺对电离辐射损伤小鼠小肠保护作用研究
- Author:
Ying LIU
;
Hong JIN
;
Zhiqing XU
;
Xianyuan WANG
;
Wenkao NAN
- Publication Type:Journal Article
- Keywords:
glutamine;
radiation;
intestine
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the protective effect of glutamine on intestine in mice damaged by radiation. Methods: Mice were exposed to 137 Cs rays (dose of 4Gy) with the whole body. The protetive effects of glutamine on intestine radiational damages were studied. Result: After radiation, GSH contents, SOD activities, protein and DNA contents were decreased and MDA contents were increased in intestinal mucosa. Villus height was shortened, crypt depth was deepened, wall width and villus surface area were decreased. Glutamine supplement restrained the changes of indices above mentioned and made them close to normal levels. Conclusion: Glutamine supplement had the protective effect on radiation damage in mice.
