THE INFLUENCE OF RETINOIC ACID ON THE DEVELOPMENT OF LYMPH NODE B CELLS IN CHILDREN
- VernacularTitle:视黄酸对幼儿淋巴结B细胞发育的影响
- Author:
Dong WEI
;
Yi YANG
;
Weiping WANG
- Publication Type:Journal Article
- Keywords:
retinoic acid;
receptors, retinoic acid;
children;
B lymphocyte;
cell differentiation
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of retinoic acid on the differentiation and development of B lymphocytes, and explore the mechanism of vitaminA in increasing the production of antibodies. Method: In vitro cultured cells from children’s normal mesentery lymph nodes, before and after administration of retinoic acid or retinoic acid antagonist, the changes of cell surface markers were analyzed by flowcytometry to observe the differentiation and maturation of B cells. Results: During culture in vitro, the percent of mature CD19+IgM+ B cells increased and relatively immature CD19+IgM- B cells decreased gradually, and the changes were especially obvious at 48 h. The administration of retinoic acid further increased the percent of CD19+IgM+ B cells, and the enhancement was markedly at 24 and 48 h (P
