Influence of recombinant growth hormone on protein metabolismin hepatocirrhosis: an animal experiment
- VernacularTitle:重组人生长激素对肝硬化大鼠IGF-1、清蛋白mRNA的影响
- Author:
Xinyu ZHANG
;
Jianjun WANG
;
Qiang CHI
;
Sheng TAI
;
Lingwang ZHOU
;
Xiaoju QU
;
Huili GUO
;
Jiah ZHOU
- Publication Type:Journal Article
- Keywords:
Hepatocirrhosis;
Hypoproteinemia;
rhGH;
Albumin mRNA;
IGF-1
- From:
Parenteral & Enteral Nutrition
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: We observed the influence of recombinant human growth hormone(rhGH) on protein metabolism in hepatocirrhotic rats and investigated mechanisms. Methods: Ninety rats were randomized into three groups(n=30 for each group): group A(normal rats), B(cirrhotic rats) and C(cirrhotic rats receiving rhGH). Rats in group C were subcutaneously given rhGH with a dosage of 1 U/(kg?d) for up to 1 week. The plasma concentrations of albumin(ALB), prealbumin(PA), transferrin(TF) and insulin-like growth factor-1(IGF-1) were detected on experimental day 14. And liver biopsy was taken to examine the expression level of albumin mRNA with TR-PCR. Results: The albumin, prealbumin, transferrin and IGF-1 levels in groups A and C were significantly higher than those in group B. The expression level of albumin mRNA in grup C was significantly higher than that in group B. Conclusions: The rhGH can improve the level of IGF-1 in plasma and improve the expression of albumin mRNA. Moreover, it may significantly improve the synthesis of protein and attenuate hypoproteinemia in cirrhotic rats.
