The influences of different nutritional formulas and routes on the intestinal barrier inrats with gut ischemia/reperfusion injury
- VernacularTitle:大鼠肠缺血-再灌注后营养对肠黏膜屏障功能的影响
- Author:
Hao WANG
;
Guoha WU
- Publication Type:Journal Article
- Keywords:
Ischemia/reperfusion;
Bacterial translocation;
Enteral nutrition;
Parenteral nutrition;
Immunonutrition
- From:Parenteral & Enteral Nutrition
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: In this study,we evaluatedthe influence of different nutritional support routes and nutrients on the intestinal barrier function and bacterial translocation in rats with gut I/Rinjury. Methods: Eighty rats were divided randomly into: I/R group,control group,and nutrition-supportgroups. Bacterial culture, D-lactate and endotoxin levels was assayedafter 7 days of nutrition support. Results: There was serious damagein intestinal tissue of I/R group. Remarkably higher value of bacterial translocation occurred in PN group (P0.05).The endotoxin level was the highest in PN group. Conclusions: TPN alone could impair gut immune barrier function and thereforefacilitate bacterial translocation.The use of immunonutritionindicates limited efficacyin preventing bacterial translocation compared with common enteral nutrition.
