Study on the expression of a novel cDNA fragments of a multidrug resistance gene from human lung adenocarcinoma cell line in lung cancer
- VernacularTitle:肺腺癌多药耐药细胞株特异表达的新基因cDNA片段在肺癌组织中表达的研究
- Author:
Kunlin LI
;
Guoming WU
;
Guijun HUANG
- Publication Type:Journal Article
- Keywords:
lung neoplasm;
genes, MDR;
in situ hybridization;
gene expression
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of a new drug resistance-related gene cDNA fragment from human lung adenocarcinoma cell line in several types of lung cancer and their adjacent normal tissues. Methods The in situ hybridization histochemistry (ISHH) and Northern blot were employed to study the location and expression of the cDNA fragment in lung cancer cells. Results The results of ISHH and Northern blot showed that the expression of the fragment was discovered in 6 cases of 12 patients with lung adenocarcinoma, but not observed in the lung cancer tissues of other types and normal tissues(P
