Increased production of hepatic platelet activating factor (PAF) and PAF receptors in CCl_4 -induced liver cirrhosis: its implications in chronic liver injury
- VernacularTitle:肝硬化形成过程中血小板活性因子及其受体在门脉高压形成中的意义
- Author:
Xuemei MA
;
Chunping WANG
;
Jun HAN
- Publication Type:Journal Article
- Keywords:
platelet activating factor;
receptors;
hypertension, portal;
liver cirrhosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of platelet activating factor(PAF) and its receptor in portal hypertension in liver cirrhosis. Methods A model of hepatic cirrhosis was replicated in rat by intraperitoneal injection of CCL 4 for 8 weeks. The blood and hepatic PAF and PAF receptors contents were assayed with ELISA, RT-PCR and saturation binding technique. Results Compared with control rats, cirrhotic rats had higher hepatic PAF levels, hepatic PAF output, and plasma PAF levels, which were increased by 44%, 87.7% and 54.5%(P
