Gene expression of beta-catenin in human nasopharyngeal carcinoma
- VernacularTitle:鼻咽癌组织中?-连环蛋白基因表达水平的初步研究
- Author:
Junsong JIA
;
Xing DENG
;
Changxuan YOU
- Publication Type:Journal Article
- Keywords:
catenin;
nasopharyngeal neoplasms;
gene expression
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between ?-catenin gene expression and the mechanism of tumorigenesis, development and metastasis of human nasopharyngeal carcinoma. Methods RT-PCR method was used to detect the mRNA expression of ?-catenin in normal human nasopharyngeal tissues and nasopharyngeal carcinoma. Results The results showed that ?-catenin expression in 11 out of 15 nasopharyngeal carcinoma specimens was decreased (73.3%). Conclusion The abnormal expression of ?-catenin changed in the normal adhesive function and the signal transduction pathway of the cell in human nasopharyngeal carcinoma, indicating that the expression level of ?-catenin was a biological marker of tumorigenesis and development of human nasopharyngeal carcinoma.
