The expression of COX-2 VEGF-C and lymph node metastasis in human gastric carcinoma
- VernacularTitle:环氧化酶-2血管内皮生长因子-C的表达与胃癌淋巴结转移的关系
- Author:
Xiaoling WANG
;
Zhixiang SHEN
;
Jieping YU
- Publication Type:Journal Article
- Keywords:
Gastric neoplasm Cyclooxygenase-2(COX-2) Vascular endothelial growth factor-c(VEGF-C) Immunohistochemistry Lymph node metastasis
- From:
Chinese Journal of Practical Internal Medicine
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was designed to investigate the relationship between COX-2 and VEGF-C in human gastric carcinomas and discuss the significance of COX-2、VEGF-C in lymph mode metastasis.Methods Forty-two gastric carcinoma tissues and twenty adjacent noncancerous specimens were obtained from surgical resections.COX-2,VEGF-C protein expression was evaluated by immunohistochemical analysis.Results (1)COX-2 was overexpressed in 25 of 42 carcinoma tissues (59.5%) and VEGF-C was 27 of 42(64.3%),which were significantly higher than those in noncancerous tissues (P0.05).(3)There was positive correlation between the expression of COX-2 and VEGF-C(r=0.425,P
