Association between luteinizing hormone ?-subunit gene Gly102Ser polymorphism and polycystic ovary syndrome and premature ovarian failure
- VernacularTitle:黄体生成素﹀基因Gly102Ser多态性与多囊卵巢综合征及卵巢早衰的关系
- Author:
Xuanli CHEN
;
Jing YANG
;
Wangming XU
;
Zhuoni XIAO
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
premature ovarian failure;
luteinizing hormone;
polymorphism
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between luteinizing hormone(LH) ?-subunit gene Gly102Ser polymorphism and polycystic ovary syndrome and premature ovarian failure. Methods: The LH? gene Gly102Ser polymorphism was analyzed in polycystic ovary syndrome(70 cases),premature ovarian failure(34 cases) and normal group(90 cases) by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results: The LH? gene allelic frequencies of A,G were 0.100, 0.900;0.079,0.921;0.017,0.983 in PCOS,POF and control groups, respectively. The A allele frequencies of LH? gene in PCOS and POF were higher than those in control groups(? 2=10.872,4.413,P0.05). Conclusion: The LH? gene Gly102Ser polymorphism exists in both PCOS and POF people,which is associated with PCOS but not related to POF,and might be a risk factor for PCOS.
