Gap junctional intercellular communication and cancer
- VernacularTitle:细胞间隙连接通讯与肿瘤
- Author:
Hua SUN
;
Gengtao LIU
- Publication Type:Journal Article
- Keywords:
gap junctional;
cancer;
bicyclol
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Gap junctional intercellular communication (GJIC) has been specu la ted to be a necessary biological function of metazoan cells for the regulation o f growth control, differentiation and apoptosis of normal progenitor cells. Rese arches show that most transformed cells and tumor cells have reduced or abolished GJIC. The prevention of the down regulation of GJIC by the tumor promoters or the restoration of GJIC in neoplastic cells may have potential in prevention and therapy of cancer.
