New light on nomegestrol acetate pharmacological profile
- VernacularTitle:醋酸诺美孕酮药理作用研究进展
- Author:
Yan ZHU
;
Zuyue SUN
;
Lin CAO
- Publication Type:Journal Article
- Keywords:
nomegestrol acetate;
breast cancer;
elective estrogen enzyme modulators;
multidrug resistance;
endometrial proliferation
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Nomegestrol acetate, 19-norprogesterone de ri vatives, has been used for oral contraception. Recently, studies showed that nom egestrol was a selective estrogen enzyme modulator (SEEM). Nomegestrol is capabl e of inhibiting estrone sulfatase and 17-beta-hydroxysteroid dehydrogenase (17 beta-HSD) and increasing the activity of sulfotransferase,which will provide a new option in the treatment of breast cancer. In addition, nomegestrol has stro ng reversal effects on multidrug resistance in breast cancer cells. In vitro, nomegestrol also exhibits as an inhibitor on endometrial proliferation in uter us. These advances will be introduced in the present review.
