Effects of probucol on the metabolism of high density lipoprotein cholesterol and their mechanism
- VernacularTitle:普罗布考对高密度脂蛋白胆固醇代谢的影响及其作用机制
- Author:
Shaocai HONG
;
Shuiping ZHAO
- Publication Type:Journal Article
- Keywords:
probucol;
cholesterol, high-density lipoprotein;
meta bolism
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Probucol is a hypolipidemic agent with a unique pharm ac odynamic and clinical profile. It has a significant antiatherosclerogenic role a lthough it causes a marked decrease in serum high-density lipoprotein (HDL)-ch olesterol levels. The metabolism of HDL in vivois unclear. Some preliminary investigations suggest a beneficial effect in enhancing reverse cholesterol tra nsport which contributes to antiatherosclerosis of probucol. This paper reviews the mechanism of HDL-lowering effects of probucol.
