Inhibition of BN IL-1?-induced fever and effects on cAMP in POA and plasma
- VernacularTitle:BN对IL-1?致热的抑制作用及POA和血中cAMP的影响
- Author:
Lei TONG
;
Liang ZHANG
;
Xiaolan WU
;
Yan LI
;
Lidan LIU
;
Shufen ZHAO
- Publication Type:Journal Article
- Keywords:
bombesin;
interlukin-1?;
cAMP;
fever
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of Bombesin(BN) on hypothermia of rats and its relation with cAMP.Methods SD male rats were dealed with intracerebroventricular administration of bombesin and IL -1?. Change in body temperature was measured and content of cAMP in hypothalam us and plasma was detected. Results ①In the febrile rats induced by icv. injection of IL-1?, cAMP level in POA and plasma was significantly higher (P
