Effect of puerarin on reperfusion injury after thrombolytic therapy in acute pulmonary thromboembolism
- VernacularTitle:葛根素对急性肺血栓栓塞溶栓治疗后再灌注损伤的影响
- Author:
Shaoxian CHEN
;
Qinhua JIANG
;
Liangxing WANG
;
Yanfan CHEN
;
Yupeng XIE
;
Huanbin LI
;
Qi ZHANG
;
Xiaofang FAN
- Publication Type:Journal Article
- Keywords:
Puerarin;
pulmonary thromboembolism;
thrombolytic therapy;
reperfusion injury
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of puerarin on reperfusion injury after thrombolytic therapy in acute pulmonary thromboembolism and its mechanism. Methods Thirty-two Japanese rabbits were randomly divided into sham operation group (group S),Thrombolysis-only group(group T), and Puerarin group(group Pur). Acute pulmonary thromboembolism models of rabbits were established with injection of autologous blood clots through the right heart catheters,haemodynamic monitoring was performed by introducing heart catheter through right jugular vein.The activity of plasma superoxide dismutase (SOD) and content of plasma malondialdehyde (MDA) were detected before embolization,2 h after embolization,2 h and 4 h after thrombolysis. At the end,the rabbits were sacrificed and their lung,removed for histopathologic and electron microscopic investigations. Results ①Pulmonary arterial mean pressure (PAMP) were decreased at 1 hour after thrombolysis both in group T and group Pur(P
