Effects of Naloxone on plasma level ?-endorphinl in rats with alcoholic fatty liver
- VernacularTitle:纳洛酮对鼠酒精性脂肪肝血浆?内啡肽水平的影响
- Author:
Shaoqi CAO
;
Shiyun TAN
;
Zhiqiang FENG
;
Zhixiang SHEN
- Publication Type:Journal Article
- Keywords:
naloxone;
alcoholic fatty liver(AFL);
?-endorphin(?- EP);
rats
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effect of naloxone on th e plasma level of ?-endorphin (?-EP) in rats with alcoholic fatty liver (AFL) and its possible mechanism. Meth ods Forty-eight Wistar male rats were divided randomly into four grou ps: Model group (n 12), low doses treatment group (n12), high doses tre atment group (n12) and normal control group (n12). By the end of the f ourth week, all the rats were weighted, narcosised, sacrificed, and got the whol e liver. The level of ?-EP in plasma and the level of superoxidized dismutase (SOD) and malondialdehyde (MDA) in plasma and liver tissue were measured.The liv er samples were analyzed for histopathology with microscope. Results Rat models of AFL were established successfully. The level of plasma SOD i ncreased while MDA and ?-EP decreased in low doses treatment group and high do ses treatment group markedly contrast with model group (P
