Protective effects of prostaglandin E_1 on ischemia/reperfusion-induced lung injury after lung transplantation in rats
- VernacularTitle:前列腺素E_1对大鼠移植肺再灌注损伤的保护作用
- Author:
Yongan ZHOU
;
Kun LIU
;
Tao ZHANG
;
Zhongping GU
- Publication Type:Journal Article
- Keywords:
lung transplantation;
ischemia-reperfu-sion;
prostaglandin E1;
tumor necrosis factor ?
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protective effects and the mechanisms of prostaglandin E1 (PGE1 ) on ischemia/reperfusion (I/R)-induced lung injury after lung transplantation in rats. METHODS: 36 SD rats were randomly divided into 3 groups ( n = 12 in each) : sham operation group ( control group) , lung transplantation (LT)group and PGE1 treatment group. PGE1 was administered to the rats through intra-venous way from 10 min before the operation to the end of the reperfusion. The wet/dry ratio of lung, lung permeability index and neutro-phil percentage were detected in bronchoalveolar lavage fluid (BALE). Superoxide dismutase (SOD) and malond-ialdehyde (MDA) of lung tissue were measured by color-imetry. Serum level of tumor necrosis factor ?(TNF?)was detected by enzyme-linked immunosorbent assay (ELISA). RESULTS: The wet/dry ratio of lung, lungpermeability index and neutrophils percentage in BALF and MDA content of lung tissue in LT group were higher than those in control group( P
