Effects of fluvastatin on expression of intercellular adhesion molecule-1 after myocardial ischemia-reperfusion in rabbits with hyperlipidemia
- VernacularTitle:氟伐他汀对高脂血症兔心肌缺血再灌注损伤心肌局部细胞间粘附分子-1的影响
- Author:
Jinmei QIN
;
Bo YANG
;
Jianjun LI
;
Li CHEN
;
Shuhua DAI
- Publication Type:Journal Article
- Keywords:
fluvastatin;
myocardial ischemia- reper-fusion;
intercellular adhesion molecule-1;
hyperlipidemia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of fluvas-tatin on expression of intercellular adhesion molecule-1 after myocardial ischemia-reperfusion in rabbits with hyper-lipidemia. METHODS: 30 rabbits which were gastric perfusion administered intralipid were randomly divided into 3 groups ( n - 10 in each) : IR ( ischemia-reperfusion) group, S (sham-operation) group and F (fluvastatin 10 mg?kg-1 ) group. Electrocardiography and cardiac function were recorded during the experiment. At the end of reperfusion, ischemic area and infarct size were defined by Evans blue and triphenyltetrazolium chloride staining. The expression of ICAM-1 in myocardium was measuredby RT-PCR. RESULTS: After ischemia-reperfusion, the expression of ICAM-1 mRNA in myocardial and infarct size decreased and cardiac function significantly improved in F group compared with IR group. CONCLUSION: The increase of expression of ICAM-1 mRNA in myocardial may be one of the important factors in inducing myocardial ischemia-reperfusion injury. The myocardial protective mechanism of fluvastatin maybe attribute to its effect on decreasing the expression of ICAM-1 mRNA in myocardial .
