Effects of dexamethasone on iNOS in pulmonary tissues of rats during simulated weightlessness
- VernacularTitle:地塞米松对尾悬吊大鼠肺组织诱导型一氧化氮合酶的影响
- Author:
Congjun HAO
;
Changting LIU
;
Junfen WANG
- Publication Type:Journal Article
- Keywords:
dexamethasone;
weightlessness simulation;
nitric-oxide synthase;
lung
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of dexamethasone on inducible nitric oxide synthase (iNOS) in pulmonary tissues of tail-suspended rats simulating weightlessness. Methods Twenty Sprague-Dawley male rats were randomly divided into 2 groups: tail-suspended for 7 days (n=10) without treatment and dexamethasone treatment group (n=10). Tail-suspension was used to simulate weightlessness. The expression of iNOS in the pulmonary tissue was examined by Western blot and immunohistochemistry. Results The results showed that the level of iNOS in the pulmonary tissue of treatment group was decreased significantly(P
