Adiponectin in patients with obstructive sleep apnea syndrome

VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患者血清脂联素水平的研究
Author: Li LIANG ; Jiayun MA ; Zhuying GUO ; Jingjuan LU ; Yanhong ZHAO
Publication Type:Journal Article
Keywords: Sleep apnea,obstructive/ME; Adiponectin/ME; Insulin resistance
From: Journal of Chinese Physician 2011;13(10):1339-1341,1345
CountryChina
Language:Chinese
Abstract: Objective To investigate the changes of serum adiponectin level and insulin resistance in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods 80 adult habitual snorers were divided into mild,moderate,severe OSAHS groups and control group,based on their apnea hypopnea index (AHI).Correlative clinical data were measured and analyzed.Results Serum adiponectin level [( 5.44 ± 2.57 ) mg/L] was significantly lower and HOMA-insulin resistance index ( 3.42 ± 0.70) was significantly higher in severe group than other groups ( P ＜ 0.05 ).Serum adiponectin level was negatively correlated with BMI,waist hip ratio,neck circumferences and et al( r =-0.233 ～ -0.499,P ＜0.05),but it was positively correlated with lowest oxygen saturation ( LSaO2 ),Ⅲ + Ⅳ％ and REM％ ( r =0.270～ 0.429,P ＜ 0.05).Conclusions Both hypoadiponectinemia and insulin resistance were observed in severe OSAHS patients.The related risk factors of hypoadiponectinemia in OSAHS might include obesity,disordered sleep architecture and other adipokines.