Transplantation of autologous peripheral blood stem cells for the treatment of diabetic foot in 26 cases
- VernacularTitle:自体外周血干细胞移植治疗糖尿病足26例临床研究
- Author:
Xiaofeng YANG
;
Yanxiang WU
;
Hongmei WANG
- Publication Type:Journal Article
- Keywords:
Stem cell transplantation Autologous Diabetic foot
- From:
Chinese Journal of Practical Internal Medicine
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of autologous peripheral blood stem cells (PBSC) transplantation in 26 cases of diabetic foot.Methods From 2003-11 to 2004-07,26 patients with diabetic foot received rhG-CSF 450~600ug/d by hypodermic injection for 5 days to mobilize stem cells.On the sixth day,PBSC were collected by COBE 6.1 Spectra Version for 82~148ml.The PBSC were injected into the ischemic lower limbs and foot intramuscularly for 3?3 cm distance.The clinical and laboratory findings were monitored.Results In 26 patients receiving PBSC transplantation,obvious pain-relief was shown in 23 cases for 3~14 days,foot cold-feeling changed in 24 patients after 2~7 days,foot ulcer improved in 4 cases after 4~12 weeks.ABI increased in 6 cases.Digital subtraction angiographic scores were peformed in 2 patients after 8 weeks,and there was new collateral vessels formation.No related complication or adverse effects were observed in all process.Conclusion Autologous PBSC transplantation might be a safe and effctive method for diabetic foot.
