Molecular biology of 5-lipoxygenase
- VernacularTitle:5-脂氧合酶的分子生物学研究
- Author:
Hong LIU
;
Bin ZHOU
;
Xinshen CHEN
- Publication Type:Journal Article
- Keywords:
leukotriene;
5-lipoxygenase;
nuclear localization sequence;
translocation
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
5-lipoxygenase (5LO) is the key enzyme in the synthesis of leukotrienes, which are potent biological mediators of inflammation and anaphylaxis.After lock out of the 5LO gene by homologous recombination in embryonic stem cells, 5LO deficient-mice can develop normally and stay healthy, with a selective opposition to certain inflammatory insults. The cellular distribution of 5LO in unstimulated cells among different cell types is different; it can present in the cytosol, the nucleus, or both. 5LO was also found capable of shuttling in and out of the nucleus under certain conditions. It is suggested that 5LO might have other functions besides its traditional catalytic role.
