Chitin enhances neural reconstruction after sciatic nerve injury in rats
- VernacularTitle:大鼠坐骨神经损伤后几丁质在神经再生修复中作用的研究
- Author:
Saiyu CHENG
;
Huaizhen RUAN
;
Xigui WU
;
Jinhai ZHANG
- Publication Type:Journal Article
- Keywords:
chitin;
peripheral nerve;
injury;
functional recovery
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of chitin on the functional recovery after sciatic nerve axotomy. Methods Upon silicone-tubulization of the transected sciatic nerve in the adult rats, either 0.9% saline or 1% chitin solution was injected into the silicone chamber. The status of functional recovery of the injured sciatic nerve was observed by electrophysiological analysis, hydrogen-peroxide oxidoreductase (HRP) retrograde trace method, and axon morphometric analysis at 30 and 90 d respectively after sciatic nerve transection. Results ① Chitin shortened the latent period of CMAP by 1.79 ms and 1.29 ms, promoted the nerve conduction velocity by 16.00 m/s and 22.00 m/s, enhanced the amplitude by 8.17 mv and 12.42 mv, respectively, at 30 and 90 d after sciatic nerve transection (P
