Expression of hypoxia-inducible factor-1? in placental trophoblasts of pregnancy-induced hypertension
- VernacularTitle:妊娠高血压综合征胎盘滋养细胞中低氧诱导因子-1?(HIF-1?)的表达
- Author:
Yun WANG
;
Li LI
- Publication Type:Journal Article
- Keywords:
hypoxia-inducible factor-1?;
pregnancy-induced hypertension;
trophoblast
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences in expression of hypoxia-inducible factor-1? (HIF-1?) in placental trophoblasts between normal pregnancy and pregnancy-induced hypertension (PIH) and the relationship of HIF-1? expression with magnesium sulfate treatment of PIH. Methods Immunohistochemical streptavidin biotin-peroxidase complex technique (SABC) was used to examine the expression of HIF-1? in 20 cases of PIH and 20 cases of normal placenta. Three groups of PIH were divided according to the degrees of severity. The results were analyzed by computer-assisted imaging and compared by t-test. Results There was significant difference in the expression of HIF-1? between the PIH group and the control group (P
