Molecular Pathway in parkinsons disease: An update on progress
- VernacularTitle:帕金森病致病的分子研究进展
- Author:
Lizhen WANG
;
Xingzu ZHU
- Publication Type:Journal Article
- Keywords:
Parkinsons disease;
oxidative stress;
dysfunction of mitochondrial complex I;
impairment of ubiquitin-proteasomal system
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Parkinsons disease(PD) is characterized by a selective lo ss of dopaminergic neurons in the substantia nigra pars compacta. The etiology of PD is still not full y understood. Molecular pathways such as oxidative stress, mitochondrial dysfunc tion and impairment in the ubiquitinproteasomal system, are involved in the proc ess of the dopaminergic neuronal cell death and the progress of PD. The explorat ion and elucidation of these molecular pathways will provide new potential targe ts for the drug therapy of PD.
