Effects of Xiatianwu total alkaloids on learning and memory impairment and the central cholinergic function in amnesic rats
- VernacularTitle:夏天无总生物碱对痴呆大鼠学习记忆障碍及中枢胆碱能神经系统功能的影响
- Author:
Huiling ZHANG
;
Zhenlun GU
;
Yi CAO
- Publication Type:Journal Article
- Keywords:
xiatianwu total alkaloids ( XA );
Alzheimers disease;
quinolinic acid;
learning;
memory;
quinolinic acid;
acetylcholinesterase;
acetyl choline
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of Xiatianwu tota l alkaloids ( XA ) on learning and memory impairment and the central cholinergic f unction in rats with quinolinic acid microinjected into bilateral hippocampus. Methods Alzheimers disease (AD) rat models were made by damagin g bilateral hippocampus with quinolinic acid (150 nmol in 2 ?l for each hippoca mpus). XA 0.25, 0.5, 1 mg?kg -1 was administrated ig from 1 week before model established to 3 weeks after model established. Y-maze was used to measur e the learning and memory ability. The activity of the acetylcholinesterase ( AC hE ) in hippocampus and the contents of acetylcholine ( ACh ) was determined by spectrophotometry. Results Microinjection of quinolinic acid in to the rats hippocampus induced learning and memory dysfunction (P
