Progress in the research of P-gp inhibitors
- VernacularTitle:细胞膜糖蛋白P170抑制剂的研究进展
- Author:
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
tumor;
multidrug resistance;
P-glycoprotein inhibitor;
phenotype
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR) is one of the major obstacles to cancer chemotherapy. It is now well established that MDR phenotype is strongly correlated with the over expression of P glycoprotein (P gp), a membrane glycoprotein encoded by MDR1 gene. There is very great progress in the research of the P gp inhibitors in recent years. This article describes the current research state of the P gp inhibitors.
