EFFECTS OF GESTATIONAL TOBACOO AND ALCOHOL EXPOSURE ON STATURE AND NEURAL DEVELOPMENT OF OFFSPRING IN MICE
- VernacularTitle:孕期吸烟饮酒对仔鼠体格和神经发育的影响
- Author:
Yan LI
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
smoke and alcohol;
offspring;
neural development;
oxidative damage
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of prenatal tobacco and alcohol exposure on stature and neural development of offspring. Methods: Female mice were exposed to tobacco smoke and alcohol drink from D6 of pregnancy to parturition. The early physical development, neurobehavioral and antioxidative functions were measured in offspring mice. Results: Compared with control, offspring subjected to prenatal exposure showed significant reduced body and organ weights as well as reduced gestational body weight gain. It also resulted in remarkable prolonged neonatal reflexes and reduced motive, coordinative and locomotor activities. Step-down and Y-maze tests revealed marked destroyed memory and learning ability. Futhermore, MDA in offspring brain cytosol and mitochondria increased significantly and the activities of SOD, GSH-Px, CAT and GST were decreased. Conclusion: Prenatal tobacco and alcohol exposures interfere with the early physical and neural development in mice, probably related to decreased antioxidative functions.
