THE ANTIOXIDANTS AND ANTILIPEMIC EFFECTS OF FLAVONO IDS EXTRACTED FROM POMELO (CITRUS GRANDIS L OSBECK)PEEL
- VernacularTitle:柚皮黄酮类抗氧化物质的纯化及其降血脂作用研究
- Author:
Xiaoquan YANG
;
Haide ZHANG
;
Ling LI
- Publication Type:Journal Article
- Keywords:
pomelo;
flavonoids;
antioxidants;
oxidation;
blood lipids
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antioxidative and antilipemic effect of the flavonoids purified from pomelo (Citrus grandis L.Osbeck) peel. Methods: The flavonoids were isolated and purified by NKA-12 macroporous adsorption resin and the polyamide column chromatography, and preparative TLC and HPLC. DPPH radical scavenging potential and inhibition of human LDL oxidation in vitro were determined. The effects TG , TC, HDL-C and LDL-C were investigated in mice with hypercholesterolemia induced by egg yolk. Results: Three kinds of flavonoids antioxidants named P11, P12 and P2, deduced as hesperidin, naringin and eriocitrin, were purified from pomelo peel. The radical scavenging potential of P2, P11 and P12 were 52.5%, 37.8% and 39.0% respectively (P
