Effect of simulated altitude acute hypoxia on appetite and orexin mRNA expression in rats
- VernacularTitle:高原急性低氧对大鼠食欲及食欲肽mRNA表达的影响
- Author:
Jian WANG
;
Mantian MI
;
Jundong ZHU
;
Hongxi XU
- Publication Type:Journal Article
- Keywords:
High altitude hypoxia;
Appetite;
Orexin
- From:
Parenteral & Enteral Nutrition
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of simulated altitude acute hypoxia on appetite and orexin mRNA expression in rats. Methods: Rats were exposed to hypobaric chambersimulating different high altitude (3000m,4000m,5000m,6000m) for different times (8h/d;1d,3d and 7d respectively), and the changes of appetite, weight gain, and the orexin mRNA expression in hypothalamus of rats were examined. Results: With the increasement of hypoxia time and simulated altitude, the total food intake of rats and the orexin A and B mRNA expression in hypothalamus decreased gradually as compared with control. After 7 days of hypoxia, the weight gain of rats was significantly different(P
