Advances in experiment of nitric oxide and cerebral ischemia
- VernacularTitle:一氧化氮在缺血性脑损伤中作用的实验研究进展
- Author:
Huixin ZHANG
;
Jianxin ZHANG
- Publication Type:Journal Article
- Keywords:
nitric oxide;
cerebral ischemia;
nitric oxide synthase
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Many studies have showed that nitric oxide(NO) might in duce dual effects during focal cerebral ischemic injury,namely neuroprotctive and neurotoxic effects.After cerebral ischemia, NO induced by endothelial NO synthase(eNOS) has neuroprotective effect. NO induced by neuronal NO synthase(nNOS) and inducible NO synthase(iNOS) has neurotoxic effect. Dual effects of nitric oxide have been becoming novel subjects for the protection of focal cerebral ischemic injury.
