Changes of urotensinⅡ content in plasma and bronchoalveolar lavage fluid of rats with chronic hypoxic pulmonary hypertension
- VernacularTitle:低氧大鼠血浆和支气管肺泡灌洗液尾加压素Ⅱ的变化
- Author:
Boying LIU
;
Zhonghe YU
;
Shuling HAO
- Publication Type:Journal Article
- Keywords:
urotensinⅡ;
hypoxi;
pulmonary hypertension
- From:Journal of Third Military Medical University
2003;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the dynamic changes of urotensionⅡ (U Ⅱ) content in plasma and bronchoalveolar lavage fluid (BALF) of rats with chronic hypoxic pulmonary hypertension and to investigate the effects of hypoxia on the synthesis and secretion of U Ⅱ and the correlation of U Ⅱ with the mean pulmonary artery pressure (mPAP) and the partial pressure of arterial oxygen (PaO 2). Methods Male Wistar rats were randomly divided into control group and hypoxic groups. Model of chronic hypoxic pulmonary hypertension was established by normal barometric and discontinuous hypoxia. mPAP and RVdp/dt max of each rat were measured using right cardiac catheterization. PaO 2 was detected by blood gas analysis. U Ⅱcontents in plasma and BALF were detected by radioimmunoassay. Results During hypoxia, mPAP, RVdp/dt max , U Ⅱ content in plasma, and BALF increased in rats (P
