Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies.
- Author:
Akira NAKAJIMA
1
;
Yasushi OHIZUMI
;
Kiyofumi YAMADA
Author Information
1. Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, Nagoya, Japan. kyamada@med.nagoya-u.ac.jp
- Publication Type:Review
- Keywords:
Nobiletin;
Alzheimer's disease;
Memory;
Amyloid beta;
Hyperphosphorylated tau;
Oxidative stress;
Cholinergic neurodegeneration
- MeSH:
Aged;
Alzheimer Disease;
Animals;
Citrus*;
Natural Resources;
Dementia;
Humans;
Memory;
Models, Animal;
Oxidative Stress;
Pathology
- From:Clinical Psychopharmacology and Neuroscience
2014;12(2):75-82
- CountryRepublic of Korea
- Language:English
-
Abstract:
Alzheimer's disease (AD), the most common form of dementia among the elderly, is characterized by the progressive decline of cognitive function and has a detrimental impact worldwide. Despite intensive laboratory and clinical research over the last three decades, pharmacological options for the prevention and effective long-term treatment of AD are not currently available. Consequently, successful therapeutic and preventive treatments for AD are needed. When researching materials from natural resources having anti-dementia drug activity, we identified nobiletin, a polymethoxylated flavone from the peel of Citrus depressa. Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effects against pathological features of AD including amyloid-beta (Abeta) pathology, tau hyperphosphorylation, oxidative stress, cholinergic neurodegeneration and dysfunction of synaptic plasticity-related signaling, suggesting this natural compound could become a novel drug for the treatment and prevention of AD.
