Liver perfusion technique and its applications in drug study
- VernacularTitle:肝脏灌流技术及其在药物研究中的应用进展
- Author:
Huichang BI
;
Xiao CHEN
;
Mi HUANG
- Publication Type:Journal Article
- Keywords:
liver perfusion;
metabolism;
pharmacokinetics;
drug-drug interaction
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Liver perfusion technique has been used in drug study for many decades. Liver perfusion has outstanding advantages over other techniques, such as isolated hepatocytes, hepatic cell lines, and hepatocyte membrane vesicles.It is an ideal experimental model used in drug metabolism, drug-drug interactions, and pharmacokinetic studies. Liver perfusion technique, its advantages or disadvantages, and its extensive applications have been reviewed.
