Hydrogen sulfide inhibited expression of elastin in pulmonary arteries of hypoxic pulmonary hypertensive rats
- VernacularTitle:硫化氢抑制低氧性肺动脉高压大鼠肺动脉弹力蛋白的表达
- Author:
Bin ZHAO
;
Junbao DU
;
Xinmin LIU
;
Chunyu ZHANG
;
Cong WANG
;
Haiyin WANG
- Publication Type:Journal Article
- Keywords:
hydrogen sulfide;
pulmonary hypertension;
elastin;
TGF-?
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the inhibitory effect of hydrogen sulfide on expression of elastin in hypoxic pulmonary hypertensive (HPH) rats. Methods Twenty-four rats were randomly divided into three groups:control group (n=8), hypoxic group (n=8) and hypoxia+NaHS group (n=8). Pulmonary artery mean pressure (mPAP) of three group rats was measured via right ventricular catheterization. Right ventricle and left ventricle+septum of each rats were isolated from intact rats and weight of right ventricle/(weight of left ventricle+septum) ratio was calculated. The percentage of muscularized arteries of small pulmonary arteries was measured using a light microscope. The expression of elastin and TGF-? in pulmonary artery smooth muscle cells was observed with immunohistochemistry. Results mPAP and weight of right ventricle/(weight of left ventricle+septum) ratio were significantly higher in rats of hypoxic group than those of control group (P
