The therapy effect of Kadsura heteroclita on the AD model mice
- VernacularTitle:广东海风藤提取物HS_2对老年痴呆小鼠的药效学研究
- Author:
Fei XIAO
;
Huanmin LUO
;
Xiaoguang LI
;
Peifen ZHANG
;
Wen WENG
;
Qi GAO
- Publication Type:Journal Article
- Keywords:
kadsura heteroclita;
Alzheimers disease;
aluminium;
learning and memory;
amyloid beta-protein;
senile plaque
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The pharmacodynamics and mechanism of Kadsura heteroclita on the Alzheimers disease (AD) model mice were studied. Methods The Kunming mice were treated with D-galactose and AlCl 3(90 d)to make the AD animal model. The therapy groups were treated with HS 2 (po, 40 d) respectively since d51. The Morris water-maze test, the expressions of PS1, BACE, as well as the pathological observation of the hippocampus and cerebral cortex were carried out to evaluate the effect of HS 2 on the AD model mice. Resluts By oral administration with HS 2, the capacity of learning and memory of the AD model mice was improved. HS 2 can downregulate the expression of PS1, BACE and decrease the amount of senile plaque in their brains. Conclusion HS 2 can meliorate AD model mice's learning and memory deficiency as well as decrease the mRNA content of PS1, BACE and senile plaque in their brains.
