Inhibition of clotrimazole on Paneth cell defensins
- VernacularTitle:克霉唑对Paneth细胞防御素分泌的抑制作用
- Author:
Yu YU
;
Lian ZHOU
;
Peixun WANG
- Publication Type:Journal Article
- Keywords:
clotrimazole;
paneth cells;
defensins
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the Clotrimazoles (CLT) inhibitive effect on the secretion of ?-defensins of the Paneth cells.Methods The ?-defensin mRNA expression is determined by semi-quantitative RT-PCR. The secretion of defensins is determined by dot-blot and ELISA. Results CLT has no influence on the defensin mRNA expression. All of 125 nmol?L -1, 250 nmol?L -1 and 500 nmol?L -1 CLT can inhibit the secretion of ?-defensins. Conclusion CLT could inhibit the secretion of defensins, which suggests that CLT maybe influence the function of small intestine
