Establishment and application of apparatus for the continued measurement of the oxygen consumption in mice
- VernacularTitle:小鼠耗氧量动态变化测定装置的建立与应用
- Author:
Yunsheng GAO
;
Yongxiu QI
;
Ke LI
;
Yuyun ZHU
;
Liyong HAO
;
Jian MA
;
Xiaoming XIN
- Publication Type:Journal Article
- Keywords:
oxygen consumption;
measuring apparatus;
tolerance hyoxia;
mice;
propranolol
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To establish a set of apparatus and method for the continued measurement of the oxygen consumption in mice. Methods The apparatus consists of a bottle with broad-neck for mice, basic burette, beaker containing water and some tubes for connection. Twenty mice were divided randomly into two groups and administered intragestrically propranolol 20 mg?kg -1 or equal volume of normal saline, respectively. The survival time and oxygen consumption were measured in mice subjected to normobaric and hypoxia.Results The survival time was prolonged by 43.35% (P
