Clinical evaluation of radio-heating-chemotherapy in treatment of patients with malignant pleural effusion
- VernacularTitle:射频透热联合化疗治疗恶性胸腔积液的临床评价
- Author:
Zufeng GUO
;
Banghui ZHANG
;
Jin CHENG
- Publication Type:Journal Article
- Keywords:
radio-heating-chemotherapy;
intravenous chemotherapy;
cisplatin;
malignant pleural effusion;
karnofsky performance status(KPS) score
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the efficacy and safety on the radio-heating-chemotherapy in treatment of patients with malignant pleural effusion (MPE). METHODS: 60 patients of MPE were randomly devided into two groups, radio-chemotherapy group (treatment group) and chemotherapy group (control group). The drugs, according to the types of tumor cells, were select to take intravenous injection and pleural cavity administration. The patient’s pleural cavity was drained continuously by pleurocentesis. These treatments were made once two week lasting for 4-6 weeks with NS 30 ml+cisplatin 60 mg by perfusion of pleural cavity. After the perfusin of pleural cavity, radio-heating was performed 60-90 min, twice one week for 8-10 times in the treatment group. RESULTS: The response rate was 90% (CR+PR) in the treatment group, and 67% (CR+PR) in the control group. The rates were higher than those in the control group (P
