Relationship of expression of clusterin with expressions of bcl-2 and p53 in prostate epithelia
- VernacularTitle:Clusterin、bcl-2及p53在前列腺上皮组织中的表达及相关性研究
- Author:
Gang CHEN
;
Wei TANG
- Publication Type:Journal Article
- Keywords:
prostatic neoplasm;
apoptosis;
clusterin;
p53;
bcl-2;
immunohistochemistry
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of an inhibitor gene of apoptosis, clusterin, in prostate cancer and its relationship with the genesis and progression of prostate cancer and with the expressions of bcl 2 and p53. Methods The expressions of clusterin, bcl 2, and p53 in 10 cases of normal prostatic tissues, 15 cases of benign prostatic hyperplasia (BPH), and 49 cases of prostate cancer were examined by immunohistochemical staining. Results The rates of strong positive or weak positive of clusterin in normal prostatic tissues, BPH, and prostate cancer were 10% (1/10), 66.6% (10/15), and 91.8% (45/49), respectively. The expression level of clusterin in prostate cancer tissues was significantly higher than that in normal prostatic tissues ( P
